PERTZYE is the only pancreatic enzyme replacement therapy (PERT) containing bicarbonate-buffered enteric-coated microspheres.

Indications & Usage

PERTZYE is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis or other conditions.

Warnings & Precautions

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Fibrosing colonopathy is associated with high-dose use of pancreatic enzyme replacement. Exercise caution when doses of PERTZYE exceed 2,500 lipase units/kg of body weight per meal (or greater than 10,000 lipase units/kg of body weight per day).

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To avoid irritation of oral mucosa, do not chew PERTZYE or retain in the mouth.

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Hyperuricemia may develop. Consider monitoring uric acid levels in patients with hyperuricemia, gout, or renal impairment.

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Exercise caution when administering pancrelipase to a patient with a known allergy to proteins of porcine origin.

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There is theoretical risk of viral transmission with all pancreatic enzyme products including PERTZYE.

Adverse Reactions

The most common adverse reactions (≥ 10%) are: diarrhea, dyspepsia, and cough.

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